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GPCR and Signal Transduction laboratory;

With a team of passionate scientists and cutting-edge technology, we strive to unravel the complexities of GPCR signaling pathways and their impact on human health. Our laboratory uses bioinformatics tools for discovering new potential biotherapeutic drug candidates. Subsequently, we analyze the biochemistry and physiology of the new potential biotherapeutic drug candidates. In addition, we are also using peptide and protein engineering technology to take the potential biotherapeutic drug to the clinical tests by checking their efficacy using animal models. Through dedicated research, recently a promising bio-venture company was founded with the motto to utilizes various research techniques to develop into true first-in-class drugs.


본 연구실은 생물정보학을 기반으로 새로운 신약후보물질을 발굴한다. 신약후보물질에 대한 생화학적 생리적 분석을 통하여 후보물질로서의 가능성을 연구한다. 또한 펩타이드/단백질 공학적 방법을 이용하여 후보물질을 실제 약물로 개발하여 동물모델에서 그 효능을 평가한다. 본 연구를 통해 유망한 바이오벤처 기업을 창업하였다. 진정한 의미의 First-in-class 약물 개발을 위한 다양한 연구기법을 활용한다.

1. 생물정보학 - Bioinformatics

Discovering novel neuropeptides acting on orphan GPCRs

Evolutionary genomics for neuropeptides and GPCRs

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2. 생화학/생리적 분석법 - Biochemical analysis & Physiogical analysis 

Explore GPCRs signaling pathway 

GPCRs and arrestin interaction

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NanoBiT-based Cytosolic Calcium sensor

Application of CRISPR/Cas 9 in study of cell mediate response 

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GPCR internalization study

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Molecular interaction between neuropeptides and GPCRs

Neural networks for neuropeptides and GPCRs

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3. 약물디자인 및 동물모델에서의 효능평가 - Drug Design and its efficacy in the animal model

Designing potential drug candidates

In vitro and in vivo efficacy of drug candidates

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