GPCR & Signal Transduction lab
GPCR and Signal Transduction laboratory;
With a team of passionate scientists and cutting-edge technology, we strive to unravel the complexities of GPCR signaling pathways and their impact on human health. Our laboratory uses bioinformatics tools for discovering new potential biotherapeutic drug candidates. Subsequently, we analyze the biochemistry and physiology of the new potential biotherapeutic drug candidates. In addition, we are also using peptide and protein engineering technology to take the potential biotherapeutic drug to the clinical tests by checking their efficacy using animal models. Through dedicated research, recently a promising bio-venture company was founded with the motto to utilizes various research techniques to develop into true first-in-class drugs.
본 연구실은 생물정보학을 기반으로 새로운 신약후보물질을 발굴한다. 신약후보물질에 대한 생화학적 생리적 분석을 통하여 후보물질로서의 가능성을 연구한다. 또한 펩타이드/단백질 공학적 방법을 이용하여 후보물질을 실제 약물로 개발하여 동물모델에서 그 효능을 평가한다. 본 연구를 통해 유망한 바이오벤처 기업을 창업하였다. 진정한 의미의 First-in-class 약물 개발을 위한 다양한 연구기법을 활용한다.
1. 생물정보학 - Bioinformatics
Discovering novel neuropeptides acting on orphan GPCRs
Evolutionary genomics for neuropeptides and GPCRs
2. 생화학/생리적 분석법 - Biochemical analysis & Physiogical analysis
Explore GPCRs signaling pathway
GPCRs and arrestin interaction
NanoBiT-based Cytosolic Calcium sensor
Application of CRISPR/Cas 9 in study of cell mediate response
GPCR internalization study
Molecular interaction between neuropeptides and GPCRs
Neural networks for neuropeptides and GPCRs
3. 약물디자인 및 동물모델에서의 효능평가 - Drug Design and its efficacy in the animal model
Designing potential drug candidates
In vitro and in vivo efficacy of drug candidates